The Platt Laboratory asks a simple but powerful question: how do changes in the cell’s internal organization shape the biology of human disease? Our work has defined condensate dysfunction, in which membraneless compartments lose integrity and fail to organize biomolecules, and identified proteolethargy, a pathological reduction in protein mobility that impairs cellular function. These findings suggest that common stressors disrupt cellular organization and contribute to chronic disease, motivating a broader effort to define cellular organization as a fundamental dimension of human pathology.
Affiliations
The Platt Laboratory is part of the Division of Gastroenterology & Hepatology in the Department of Medicine and is affiliated with several centers and programs at Weill Cornell Medicine.
Join the Lab
We’re always interested in connecting with thoughtful, ambitious scientists who want to understand how cellular organization shapes disease. Open positions for Research Assistants, PhD and MD-PhD students, Postdoctoral Fellows, and Clinical Fellows. Please reach out to learn more