The Platt Laboratory asks a simple but powerful question: how do changes in the cell’s internal organization shape the biology of human disease? Our work has defined condensate dysfunction, in which membraneless compartments lose integrity and fail to organize biomolecules, and identified proteolethargy, a pathological reduction in protein mobility that impairs cellular function. These findings suggest that common stressors disrupt cellular organization and contribute to chronic disease, motivating a broader effort to define cellular organization as a fundamental dimension of human pathology.
Affiliations
The Platt Lab is part of the Division of Gastroenterology in the Department of Medicine and is affiliated with several centers and institutes at Weill Cornell Medicine, including the Joan and Sanford I. Weill Center for Metabolic Health, and the Cell and Developmental Biology Graduate Program.